I agree with you that there is no unworkable pairing out there. A good writer can successfully put any two characters together.

I understand OTP in some ways, even though I don't share the impulse. It's like wearing the same perfume every day or watching reruns of Sitcoms or having roughly the same schedule of meals every week. It's familiar and comforting and you know you like it and that you won't be disappointed by what you find there. Which there is certainly something to be said for.